Novel insights into G protein and G protein-coupled receptor signaling in cancer
نویسندگان
چکیده
منابع مشابه
G-protein Coupled Receptor Dimerization
A growing body of evidence suggests that GPCRs exist and function as dimers or higher oligomers. The evidence for GPCR dimerization comes from biochemical, biophysical and functional studies. In addition, researchers have shown the occurrence of heterodimerization between different members of the GPCR family. Two receptors can interact with each other to make a dimer through their extracellular...
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This special issue of Biology of the Cell contains a collection of articles that correspond to work presented at the international symposium held in Paris in October 23-24, 2003 that was entitled “G Protein-Coupled Receptors : New insights into signaling and regulation“ (see Meeting Report, this issue). G Protein-Coupled Receptors (GPCRs) are also called heptahelical or serpentine receptors bec...
متن کاملG protein-coupled receptor accessory proteins and signaling: pharmacogenomic insights.
The identification and characterization of the genes encoding G protein-coupled receptors (GPCRs) and the proteins necessary for the processes of ligand binding, GPCR activation, inactivation, and receptor trafficking to the membrane are discussed in the context of human genetic disease. In addition to functional GPCR variants, the identification of genetic disruptions affecting proteins necess...
متن کاملStructural insights into G-protein-coupled receptor activation.
G-protein-coupled receptors (GPCRs) are the largest family of eukaryotic plasma membrane receptors, and are responsible for the majority of cellular responses to external signals. GPCRs share a common architecture comprising seven transmembrane (TM) helices. Binding of an activating ligand enables the receptor to catalyze the exchange of GTP for GDP in a heterotrimeric G protein. GPCRs are in a...
متن کاملG Protein-Coupled Receptor Signaling in Stem Cells and Cancer
G protein-coupled receptors (GPCRs) are a large superfamily of cell-surface signaling proteins that bind extracellular ligands and transduce signals into cells via heterotrimeric G proteins. GPCRs are highly tractable drug targets. Aberrant expression of GPCRs and G proteins has been observed in various cancers and their importance in cancer stem cells has begun to be appreciated. We have recen...
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ژورنال
عنوان ژورنال: Current Opinion in Cell Biology
سال: 2014
ISSN: 0955-0674
DOI: 10.1016/j.ceb.2014.01.005